Glutamate is present both intracellularly and extracellularly, each serving different
purposes with respect to metabolic functions and signal transmission.[1]
谷氨酸存在於細胞內和細胞外,在代謝功能和信號傳遞方面各有不同的用途。[1]
Metabolic studies have shown that all of the glucose which enters the brain virtually
gets converted into glutamate.[3]
代謝研究表明,進入大腦的所有葡萄糖實際上都轉化為谷氨酸。[3]
More recently, it has been realized that glutamate also plays a central role
in processes underlying the development and maintenance of addiction.
These processes include reinforcement, sensitization, habit learning and reinforcement
learning, context conditioning, craving and relapse.
最近,已經認識到谷氨酸在成癮的發展和維持基礎的過程中也起著中心作用。這些過程包括強化,敏銳度,習慣學習和強化學習,情境調節,渴望和復發。
Addictive behavior does not result from repeated drug exposure per se,
but is a result of learning.
上癮的行為並非源於反復的藥物暴露本身,而是學習的結果。
GABAA receptors form the major class of inhibitory neurotransmitter receptors in
the mammalian brain.
GABA A受體是哺乳動物腦中主要的抑制性神經遞質受體。
and make a first attempt to bring together evidence from several fields to understanding potential involvement of GABAA receptor subtypes in addictive behaviour.
並首次嘗試將來自多個領域的證據匯集,了解GABAA受體亞型可能與成癮行為有關。
偏頭痛治療總整理(缺鎂鋅銅維它命C、B6,建議善存+多喝豆漿。)
告訴我們:
β-丙氨酸和牛磺酸也能激活GABAA受體
富含丙氨酸的蔬菜
Seaweed, laver,Soybeans,Lentils,Potato
海藻,紫菜,大豆,扁豆,馬鈴薯
L-脯氨酸可以強烈激活GABA-B受體
脯氨酸豐富的蔬菜
Soybeans,Potatoes,Cabbage,Lentils
大豆,馬鈴薯,白菜,扁豆
鎂拮抗NMDA受體(Zhu和Auerbach,2001),並表現出GABAA受體激動劑活性。
GABA是所有GABA受體的激動劑
GABA由L-Glutamate(谷氨酸)經由L-Glutamate decarboxylase(L-谷氨酸脫羧酶)產生GABA
谷氨酸脫羧酶(GAD)催化谷氨酸向GABA的轉化。
維生素B6對GAD的顯著激活率